Large Language Model Agents for Biological Intelligence Across Genomics, Proteomics, Spatial Biology, and Biomedicine

Published:

This review synthesizes more than 60 LLM-based agent systems across genomics, proteomics, single-cell and spatial biology, drug discovery, bioinformatics workflows, and biomedical applications. It proposes a cross-domain taxonomy and highlights evaluation, grounding, reproducibility, and safety challenges.

Sajib Acharjee Dip, Dipanwita Mallick, Uddip Acharjee Shuvo, Shovito Barua Soumma, Fazle Rafsani, Bikash Kumar Paul, Nazifa Ahmed Moumi, Shafayat Ahmed, Liqing Zhang
Briefings in Bioinformatics 2026 Paper