Large Language Model Agents for Biological Intelligence Across Genomics, Proteomics, Spatial Biology, and Biomedicine

Published in Briefings in Bioinformatics, Volume 27, Issue 2, 2026

This review synthesizes more than 60 LLM-based agent systems across genomics, proteomics, single-cell and spatial biology, drug discovery, bioinformatics workflows, and biomedical applications. It proposes a cross-domain taxonomy and highlights evaluation, grounding, reproducibility, and safety challenges.

Recommended citation: Dip, Sajib Acharjee, et al. (2026). "Large Language Model Agents for Biological Intelligence Across Genomics, Proteomics, Spatial Biology, and Biomedicine." Briefings in Bioinformatics 27(2): bbag110.
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